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Heartflow Clinical Evidence Summary



  1. Douglas PS, et al. 1-Year Outcomes of FFRCT-Guided Care in Patients With Suspected Coronary Disease: The PLATFORM Study. J Am Coll Cardiol 2016;68(5):435-45. Publication
  2. Hlatky MA, et al. Quality-of-Life and Economic Outcomes of Assessing Fractional Flow Reserve With Computed Tomography Angiography: PLATFORM. J Am Coll Cardiol 2015;66(21):2315-23. Publication (open access)
  3. Douglas PS, et al. Clinical outcomes of fractional flow reserve by computed tomographyic angiography-guided diagnostic strategies vs. usual care in patients with suspected coronary artery disease: the prospective longitudinal trial of FFR(CT): outcome and resource impacts study. Eur Heart J 2015;36(47):3359-67. Publication (open access)

Real World Experience

  1. Curzen NP, et al. Does the Routine Availability of CT-Derived FFR Influence Management of Patients With Stable Chest Pain Compared to CT Angiography Alone?: The FFRCT RIPCORD Study. JACC Cardiovasc Imaging 2016;9(10):1188-94. Publication
  2. Nørgaard BL, et al. Clinical Use of Coronary CTA-Derived FFR for Decision-Making in Stable CAD. JACC Cardiovasc Imaging 2016 [Epub ahead of print April 7]. Publication


  1. Nørgaard BL, et al. Influence of Coronary Calcification on the Diagnostic Performance of CT Angiography Derived FFR in Coronary Artery Disease: A Substudy of the NXT Trial. JACC Cardiovasc Imaging 2015;8(9):1045-55.  Publication (open access)
  2. Gaur S, et al. Rationale and design of the HeartFlowNXT (HeartFlow analysis of coronary blood flow using CT angiography: NeXt sTeps) study. J Cardiovasc Comput Tomogr 2013;7(5):279-88. Publication (open access)
  3. Nørgaard BL, et al. Diagnostic performance of non-invasive fractional flow reserve derived from coronary CT angiography in suspected coronary artery disease: The NXT Trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps). J Am Coll Cardiol 2014;63(12):1145-55.  Publication (open access)

Scientific Basis

  1. Taylor CA, et al. Computational Fluid Dynamics Applied to Cardiac Computed Tomography for Noninvasive Quantification of Fractional Flow Reserve: Scientific Basis. J Am Coll Cardiol 2013;61:2233. Publication (open access)
  2. Zarins CK, et al. Computed Fractional Flow Reserve (FFRCT) Derived from Coronary CT Angiography. J Cardiovasc Trans Res 2013;6:708-14. Publication (open access)
  3. Serruys PW, et al. Non-invasive fractional flow reserve: scientific basis, methods and perspectives. EuroIntervention 2012;8(4):511-9. Publication


  1. Erglis A, et al. Non-invasive FFR using coronary CT angiography and computational fluid dynamics predicts the hemodynamic significance of coronary lesions. [ESC abstract #951]. Eur Heart J 2010;31(suppl_1):151-2. Publication (open access)
  2. Wijns W. Editorial Comment: The One-Stop Shop Offering Both Anatomy and Perfusion: May Well Be Opening Soon, Around the Corner. JACC: Cardiovascular Imaging 2012;5:1112-4. Publication (open access)
  3. Yoon YE, et al. Noninvasive Diagnosis of Ischemia-Causing Coronary Stenosis Using CT Angiography: Diagnostic Value of Transluminal Attenuation Gradient and Fractional Flow Reserve Computed From Coronary CT Angiography Compared to Invasively Measured Fractional Flow Reserve. JACC Imaging 2012;5:1088-96. Publication (open access)
  4. Meijs MFL, et al. CT fractional flow reserve: the next level in non-invasive cardiac imaging. Neth Heart J 2012;20:410-8. Publication (open access)
  5. Yoon YE, et al. Non-invasive functional assessment using computed tomography: When will they be ready for clinical use? Cardiovascular Diagnosis and Therapy 2012;2(2):106-12. Publication (open access)
  6. Grunau GL, et al. Modeling of Fractional Flow Reserve Based on Coronary CT Angiograpjy. Curr Cardiol Rep 2013;15:336. Publication
  7. Al-Hassan D, et al. Noninvasive fractional flow reserve derived from coronary computed tomography angiography: integrated anatomical and functional assessment. Future Cardiol 2013,9(2):243-51. Publication
  8. Kim K, et al. A Novel Noninvasive Technology for Treatment Planning Using Virtual Coronary Stenting and Computed Tomography-Derived Computed Fractional Flow Reserve. JACC: Cardiovascular Interventions 2014;7(1):72-8. Publication (open access)
  9. Onuma Y, et al. Five-Year Clinical and Functional Multislice Computed Tomography Angiographic Results After Coronary Implantation of the Fully Resorbable Polymeric Everolimus-Eluting Scaffold in Patients With De Novo Coronary Artery Disease: The ABSORB Cohort A Trial. JACC: Cardiovascular Interventions 2013;6(10):999-1009. Publication (open access)
  10. Nørgaard BL, et al. Quantitative assessment of image quality. [Abstract #233] J Cardiovasc Comput Tomogr 2013;7(3);Supplement:S83-4. Publication (open access)