HeartFlow Clinical Evidence Summary



  1. Douglas PS, et al. 1-Year Outcomes of FFR CT-Guided Care in Patients With Suspected Coronary Disease: The PLATFORM Study. J Am Coll Cardiol 2016;68(5):435-45. Publication
  2. Hlatky MA, et al. Quality-of-Life and Economic Outcomes of Assessing Fractional Flow Reserve With Computed Tomography Angiography: PLATFORM. J Am Coll Cardiol 2015;66(21):2315-23. Publication (open access)
  3. Douglas PS, et al. Clinical outcomes of fractional flow reserve by computed tomographyic angiography-guided diagnostic strategies vs. usual care in patients with suspected coronary artery disease: the prospective longitudinal trial of FFR(CT): outcome and resource impacts study. Eur Heart J 2015;36(47):3359-67. Publication (open access)
  4. Pontone, et al. Rationale and design of the Prospective LongitudinAl Trial of FFRCT: Outcome and Resource IMpacts study. Am Heart J 2015;170(3):438-46. Publication (open access)


  1. Lu MT, et al. Noninvasive FFR Derived From Coronary CT Angiography: Management and Outcomes in the PROMISE Trial. JACC Cardiovasc Imaging 2017 [Epub ahead of print Apr 7]. Publication

Real World Experience

  1. Chinnaiyan, et al. Rationale, design and goals of the HeartFlow assessing diagnostic value of non-invasive FFR CT in Coronary Care (ADVANCE) registry. J Cardiovasc Comput Tomogr 2017;11(1):62-7. Publication (open access)
  2. Kitabata, et al. Incidence and Predictors of Lesion Specific Ischemia by FFR CT: Learnings from the International ADVANCE Registry [Abstract #1297-343] J Am Coll Cardiol 2017;69(11);Supplement:297. Publication (open access)
  3. Rabbat, et al. Fractional Flow Reserve Derived from Coronary Computed Tomography Safely Reduces Invasive Coronary Angiography Rates and Cost in Patients with Stable Coronary Artery Disease [Abstract #1126-333] J Am Coll Cardiol 2017;69(11);Supplement:72. Publication (open access)
  4. Kawaji, et al. Feasibility and diagnostic performance of fractional flow reserve measurement derived from coronary computed tomography angiography in real clinical practice. Int J Cardiovasc Imaging 2017;33(2):271-81. Publication
  5. Curzen NP, et al. Does the Routine Availability of CT-Derived FFR Influence Management of Patients With Stable Chest Pain Compared to CT Angiography Alone?: The FFR CT RIPCORD Study. JACC Cardiovasc Imaging 2016;9(10):1188-94. Publication
  6. Jang, et al. The Impact of Fractional Flow Reserve Derived from Coronary Computed Tomography Angiography in a Managed Healthcare System – Kaiser Permanente Northern California [Abstract #50] J Cardiovasc Comput Tomogr 2016;10(3):S20. Publication (open access)
  7. Nørgaard BL, et al. Clinical Use of Coronary CTA-Derived FFR for Decision-Making in Stable CAD. JACC Cardiovasc Imaging 2016 [Epub ahead of print April 7]. Publication


  1. Miyoshi, et al. Non-invasive computed fractional flow reserve from computed tomography (CT) for diagnosing coronary artery disease – Japanese results from NXT trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps). Circ J 2015;79(2):406-12. Publication (open access)
  2. Nørgaard BL, et al. Diagnostic performance of non-invasive fractional flow reserve derived from coronary CT angiography in suspected coronary artery disease: The NXT Trial (Analysis of Coronary Blood Flow Using CT Angiography: Next Steps). J Am Coll Cardiol 2014;63(12):1145-55. Publication (open access)

Scientific Basis

  1. Min JK, et al. Noninvasive Fractional Flow Reserve Derived From Coronary CT Angiography: Clinical Data and Scientific Principles. JACC Cardiovasc Imaging 2015;8(10):1209-22. Publication (open access)
  2. Taylor CA, et al. Computational Fluid Dynamics Applied to Cardiac Computed Tomography for Noninvasive Quantification of Fractional Flow Reserve: Scientific Basis. J Am Coll Cardiol 2013;61:2233. Publication (open access)
  3. Zarins CK, et al. Computed Fractional Flow Reserve (FFR CT) Derived from Coronary CT Angiography. J Cardiovasc Trans Res 2013;6:708-14. Publication (open access)


  1. Cavalcante, et al. Non-Invasive Heart Team Assessment of Multivessel Coronary Disease With Coronary Computed Tomography Angiography Based on SYNTAX Score II Treatment Recommendations: Design and Rationale of the Randomised SYNTAX III Revolution Trial. EuroIntervention 2017;12(16):2001-8. Publication
  2. Ferencik, et al. The Association of High Risk Plaque Features and Non-Invasive Fractional Flow Reserve Derived from Coronary Computed Tomography Angiography in Patients with Acute Chest Pain: Results from the ROMICAT II Trial [Abstract ## 909-06] J Am Coll Cardiol 2017; 69(11); Supplement:394. Publication (open access)
  3. Ko, et al. Diagnostic Performance of Transluminal Attenuation Gradient and Noninvasive Fractional Flow Reserve Derived from 320-Detector Row CT Angiography to Diagnose Hemodynamically Significant Coronary Stenosis: An NXT Substudy. Radiology 2016;279(1):75-83. Publication (open access)
  4. Bilbey, et al. Potential impact of clinical use of noninvasive FFR CTon radiation dose exposure and downstream clinical event rate. Clinical Imaging 2016;40(5):1055-60. Publication
  5. Eftekhari, et al. Fractional flow reserve derived from coronary computed tomography angiography: diagnostic performance in hypertensive and diabetic patients. Eur Heart J Cardiovasc Imaging 2016. [Epub ahead of print Dec 24]. Publication
  6. Gaur S, et al. Coronary plaque quantification and fractional flow reserve by coronary computed tomography angiography identify ischaemia-causing lesions. Eur Heart J 2016;37(15):1220-7. Publication (open access)
  7. Nørgaard BL, et al. Influence of Coronary Calcification on the Diagnostic Performance of CT Angiography Derived FFR in Coronary Artery Disease: A Substudy of the NXT Trial. JACC Cardiovasc Imaging 2015;8(9):1045-55. Publication (open access)
  8. Kim K, et al. A Novel Noninvasive Technology for Treatment Planning Using Virtual Coronary Stenting and Computed Tomography-Derived Computed Fractional Flow Reserve. JACC: Cardiovascular Interventions 2014;7(1):72-8. Publication (open access)
  9. Gaur S, et al. Fractional flow reserve derived from coronary CT angiography: variation of repeated analyses. J Cardiovasc Comput Tomogr 2014;8(4):307-14. Publication (open access)
  10. Onuma Y, et al. Five-Year Clinical and Functional Multislice Computed Tomography Angiographic Results After Coronary Implantation of the Fully Resorbable Polymeric Everolimus-Eluting Scaffold in Patients With De Novo Coronary Artery Disease: The ABSORB Cohort A Trial. JACC: Cardiovascular Interventions 2013;6(10):999-1009. Publication (open access)

Guidelines and Recommendations

  1. Patel, et al. ACC / AATS / AHA / ASE / ASNC / SCAI / SCCT / STS 2017 Appropriate Use Criteria for Coronary Revascularization in Patients With Stable Ischemic Heart Disease: A Report of the American College of Cardiology Appropriate Use Criteria Task Force, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, and Society of Thoracic Surgeons. J Am Coll Cardiol 2017 [Epub ahead of print Mar 9]. Publication (open access)