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Unlocking the Power
of Coronary CTA

The modern way to diagnose coronary artery disease

A man looking at a monitor which shows HeartFlow analysis

The path to diagnosing coronary artery disease (CAD) hasn’t always been clear or reliable.1,2 Until now.

The CT-Flow™ pathway enables physicians to more accurately diagnose patients with suspected CAD by combining two powerful, non-invasive technologies — coronary CTA (CCTA) and the HeartFlow Analysis.1

How does the CT-Flow pathway work?

A generic CT Scanner
A 3D heart vessels model
The CT-Flow pathway begins with a CCTA. If the physician sees disease, the CCTA images are sent to HeartFlow, where AI algorithms, computational fluid dynamics and trained analysts create the HeartFlow Analysis. This personalized, color-coded 3-D model of a patient’s coronary arteries provides functional information about each blockage.

How is the CT-Flow pathway different?

To address the current gaps in cardiac diagnostic testing, the CT-Flow pathway:

  • Delivers better per-vessel diagnostic performance than other non-invasive cardiac tests1
  • Provides both anatomical and lesion-specific functional information in a single patient visit
  • Identifies functional disease other non-invasive cardiac tests may overlook1,2
  • Limits invasive testing by allowing physicians to identify patients who can be treated with optimal medical therapy alone3
  • Reduces radiation exposure by up to 50% (compared to a SPECT test)4
  • Leads to better clinical decision-making and improved patient outcomes5

How do non-invasive CAD tests compare?

Choosing the appropriate diagnostic test for your patient depends on the questions you are trying to answer and the information the test will provide. Use this chart to help determine which test is best for your patient.

CT-Flow Pathway
CT-Flow Pathway
SPECTStress EchoCoronary CTAHeartFlow Analysis
Common QuestionsA SPECT sampleA Stress Echo sampleA Coronary CTA sampleA Coronary CT Flow sample
Does my patient have CAD?XXXX
Do the vessels have plaque?XX
Where are the coronary artery specific stenoses?XX
Is there possible ischemia?XXX
What are the lesion-specific functional limitations?X
Which vessels may benefit from PCI/CABG/OMT?X
Is prognostic information provided?XXXX
Diagnostic Performance* Sensitivity: 0.42
Specificity: 0.97
AUC: 0.791
Sensitivity: 0.77
Specificity: 0.75
AUC: 0.706
Sensitivity: 0.68
Specificity: 0.83
AUC: 0.831
Sensitivity: 0.90
Specificity: 0.86
AUC: 0.941
Disadvantages1-6 Low sensitivity;
high rate of false negatives; higher radiation exposure;
lacks anatomic data
Often requires
additional testing;
lacks anatomic data
High sensitivity can lead to overutilization of invasive testing
when not paired with
functional information
Requires CCTA;
Currently not as well known as other tests
high specificity;
standard of care
no radiation
Better long-term
outcomes than
usual care testing;
lower radiation;
provides anatomic data
More accurate than
other non-invasive tests;
provides anatomic and
functional information;
lower radiation; single
patient visit

* Diagnostic performance of SPECT, CCTA and FFRCT evaluated in a head-to-head comparison for the identification of ischaemia.

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How do patients benefit?

The CT-Flow pathway addresses the current gaps in traditional diagnostic testing - where patients may be misdiagnosed due to inaccurate test results.1,2

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Frequently Asked Questions

How accurate is the CT-Flow pathway?
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The CT-Flow pathway provides the highest diagnostic performance available from a non-invasive test to help identify functional disease.1,2 This pathway leads to targeted treatment plans and a more streamlined patient experience.

How can I best incorporate CT-Flow into my practice?
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Physicians can use the CT-Flow pathway for any clinically stable symptomatic patient with CAD. The pathway requires access to a standard CT scanner and an institution that offers the HeartFlow Analysis. Find a center near you using our finder tool or contact your local HeartFlow representative.

How quickly will I get the analysis?
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Within hours, physicians can receive the HeartFlow Analysis, which is available on desktop and mobile.

How will my patients benefit?
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CT-Flow offers a streamlined workflow that reduces unnecessary invasive testing and radiation exposure, and provides more accurate information about their condition compared to other non-invasive cardiac tests.1,2,3,4 The highly visual, color-coded model resonates well with patients and can help increase adherence to treatment plans.

Is the CT-Flow Pathway approved and covered?
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Both CCTA and the HeartFlow Analysis, the two steps of the CT-Flow pathway, are commercially available. The HeartFlow Analysis is FDA cleared and reimbursed by CMS and most major commercial insurers. It’s currently available at more than 400 institutions worldwide — in the United States, United Kingdom, Europe, Canada and Japan — and has been used for more than 170,000 patients to date.

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  1. Driessen, et al. J Am Coll Cardiol 2019; Norgaard, et al, Euro J Radiol 2015.
  2. Melikian, et al. JACC: Cardiovasc Interv 2010; Jung, et al. Euro Heart J 2008. Koo, et al. J Am Coll; Cardiol 2011. Min, et al. JAMA 2012. Nørgaard, et al. J Am Coll Cardiol 2014.
  3. Patel, et al. J Am Coll Cardiol 2019.
  4. Stocker, et al. Euro Heart J 2018.
  5. Curzen, N.P., et al., J Am Coll Cardiol 2016. Newby D.E., et al. N Engl J Med 2018.
  6. Danad, et al., Euro Heart J 2017.

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