Press Release

Highmark Health’s VITAL program partners with Allegheny Health Network and HeartFlow to evaluate a novel 3D technology

New modeling tool aids physicians’ ability to identify best treatment for patients with coronary artery disease

Pittsburgh PA and Redwood City, CA (April 25, 2016) – Highmark Health, Allegheny Health Network (AHN), and HeartFlow, Inc. announced today that they are partnering to evaluate a novel non-invasive diagnostic technology that offers physicians insight into both the extent of a patient’s coronary arterial blockage and the impact the blockage has on blood flow. The partnership is part of Highmark Health’s VITAL (Verification of Innovation by Testing, Analysis and Learning) Innovation Program.

The HeartFlow Analysis uses images derived from a standard, non-invasive coronary CT angiogram (cCTA); the U.S. Food & Drug Administration (FDA)-cleared product creates a personalized, digital 3D model of each patient’s coronary arteries. Powerful computer algorithms then solve millions of complex equations to assess the impact of blockages on blood flow. This information aids physicians to determine the appropriate course of action for each patient.

“Traditionally, our options for diagnosing coronary artery disease included either a non-invasive stress test or an invasive heart catheterization.” said Moneal Shah, MD, a cardiologist at AHN and the lead investigator of this program. “With the technology from HeartFlow, we are essentially combining the information provided by a heart catheterization and a stress test through a simple non-invasive test. This is the first non-invasive technology to do this and has the potential to reduce the need for invasive testing.”

Coronary artery disease, also called coronary heart disease, is the leading cause of death for both men and women in the United States. Coronary artery disease develops when the arteries leading to the heart narrow, often because of the buildup of plaque in the vessel walls. The coronary narrowing can reduce blood flow to the heart, causing chest pain, heart attacks and death. In the United States, an estimated 16.3 million adults suffer from coronary artery disease and it is the leading cause of death worldwide, killing approximately 3.8 million men and 3.4 million women each year.1

AHN cardiologists already have reported that the HeartFlow Analysis has provided more definitive clinical information that led to an improved treatment strategy for several patients. Recently, a 78-year-old male dealing with chest pain for more than a year had two normal stress tests, but his symptoms persisted. Physician review of the coronary CT and HeartFlow analysis indicated the patient had extensive disease that would require a revascularization with two stents. Meanwhile, a 58-year-old female patient with a history of hypertension had an abnormal stress test but was able to avoid an invasive angiography when physician review of the HeartFlow Analysis indicated that her disease was not severe and medical management would be the optimal treatment.

“These examples illustrate how this innovative technology can potentially assist cardiologists to improve their diagnostic skills so that the right care can be prescribed to the right patient,” said Srinivas Murali, MD, Director of HN’s Cardiovascular Institute.

Through the VITAL program, payers are able to understand the full impact of new technologies on their members without changing insurance medical policy prematurely. Additionally, providers gain early access to novel technologies and a first-hand understanding of their impact on patients. In this way, technology vendors have the opportunity to prove the benefits of their new innovations to patients, providers and payers.

“VIT L’s mission is to leverage Highmark Health’s position as one of the largest integrated health care delivery and financing systems in the nation in order to accelerate the pace with which novel technologies and services are made available to the public,” stated David Holmberg, President and CEO, Highmark Health. “Our members and patients will be afforded access to safe new technologies that increase the quality of care and create positive patient outcomes without undue financial burden.”

About Highmark Health

Highmark Health, a Pittsburgh, PA based enterprise that employs more than 35,000 people nationwide and serves 40 million Americans in all 50 states, is the third largest integrated health care delivery and financing network in the nation. Highmark Health is the parent company of Highmark Inc., Allegheny Health Network, and HM Health Solutions. Highmark Inc. and its subsidiaries and affiliates provide health insurance to 5.3 million members in Pennsylvania, West Virginia and Delaware as well as dental insurance, vision care and related health products through a national network of diversified businesses that include United Concordia Companies, HM Insurance Group, Davis Vision and Visionworks. Allegheny Health Network is the parent company of an integrated delivery network that includes eight hospitals, a community-based network of physician organizations, and a group purchasing organization, ambulatory surgery centers, and health and wellness pavilions in western Pennsylvania. HM Health Solutions focuses on meeting the information technology platform and other business needs of the Highmark Health enterprise as well as unaffiliated health insurance plans by providing proven business processes, expert knowledge and integrated cloud-based platforms. To learn more, please visit or or contact Highmark Health at 412-544-0968.

About Allegheny Health Network

Allegheny Health Network is an integrated health care delivery system serving the western Pennsylvania region. The network is comprised of eight hospitals, including Allegheny General Hospital (its flagshipacademic medical center), Allegheny Valley Hospital, Canonsburg Hospital, Forbes Hospital, Jefferson Hospital, Saint Vincent Hospital, Westfield Memorial Hospital and West Penn Hospital; a research institute; Health + Wellness Pavilions; and a health care group purchasing organization. The network employs approximately 17,000 people, including more than 2,100 physicians on its medical staff. The network also serves as a clinical campus for both Temple University School of Medicine and Drexel University College of Medicine.

About HeartFlow

HeartFlow Inc. is a personalized medical technology company seeking to transform the way cardiovascular disease is diagnosed and treated. The company’s HeartFlow FFRCT Analysis is the first available non-invasive solution that enables a physician to more accurately evaluate whether a patient has significant coronary artery disease (CAD) based on both anatomy and physiology. The novel solution, which produces a model of the patient’s coronary arteries, is well ositioned to become an integral part of the standard of care for patients who are at risk for CAD because of its potential to improve clinical outcomes, improve the patient experience and reduce the cost of care. The HeartFlow Analysis is being utilized globally and is commercially available in the United States, Europe, Canada and Japan. For more information visit Learn more about Heartflow PLATFORM trial results here: CCM-100-083-A-HeartFlowPLATFORMACCRelease160328-final

  1. American Heart Association

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HeartFlow FFRCT 分析は、有資格の臨床医による臨床的に安定した症状のある冠状動脈疾患患者への使用を目的とした個別化された心臓検査です。 HeartFlow Analysis によって提供される情報は、資格のある臨床医が患者の病歴、症状、その他の診断検査、および臨床医の専門的判断と組み合わせて使用​​することを目的としています。


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The HeartFlow FFRCT Analysis is a personalized cardiac test indicated for use in clinically stable symptomatic patients with coronary artery disease by qualified clinicians. The information provided by the HeartFlow Analysis is intended to be used by qualified clinicians in conjunction with the patient’s history, symptoms, and other diagnostic tests, as well as the clinician’s professional judgement.

For additional indication information about the HeartFlow Analysis, please visit

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Campbell Rogers, M.D., F.A.C.C.

Executive Vice President and Chief Medical Officer

Campbell brings a wealth of experience to HeartFlow, where he serves as the Chief Medical Officer. Prior to joining HeartFlow, he was the Chief Scientific Officer and Global Head of Research and Development at Cordis Corporation, Johnson & Johnson, where he was responsible for leading investments and research in cardiovascular devices. Prior to Cordis, he was Associate Professor of Medicine at Harvard Medical School and the Harvard-M.I.T. Division of Health Sciences and Technology, and Director of the Cardiac Catheterization and Experimental Cardiovascular Interventional Laboratories at Brigham and Women’s Hospital. He served as Principal Investigator for numerous interventional cardiology device, diagnostic, and pharmacology trials, is the author of numerous journal articles, chapters, and books in the area of coronary artery and other cardiovascular diseases, and was the recipient of research grant awards from the NIH and AHA.

He received his A.B. from Harvard College and his M.D. from Harvard Medical School.